This project has pioneered simulation-based assessments of model-based science learning and inquiry practices for middle school physical and life science systems. The assessment suites include curriculum-embedded, formative assessments that provide immediate, individualized feedback and graduated coaching with supporting reflection activities as well as summative end-of-unit benchmark assessments. The project has documented the instructional benefits, feasibility, utility, and technical quality of the assessments with over 7,000 students and 80 teachers in four states.