Inquiry-based educative curricula and teachers who use these curricula as intended are major factors in achieving successful student learning outcomes in science. Educative curricula can also bring about significant change in teacher practice. Educative curricula are generally accompanied by carefully designed print teacher guides that facilitate the implementation of curricula, encourage new instructional strategies, and accommodate curriculum modifications while retaining fidelity to the developers’ content sequencing and pedagogy. An electronic teacher guide (eTG) was developed to determine whether a digital guide could better support teachers in implementing an inquiry-based curriculum and in enhancing their practice. Developed as a proof-of-concept exemplar, features of the eTG support high school teachers in planning, implementing, and modifying innovative instructional materials and in developing more ambitious teaching practices. Case studies and an online review panel suggest that certain digital features of the eTG are very useful to teachers in planning and teaching their lessons, reflecting on their practice, modifying and customizing the core curriculum, and accessing resources to augment the instructional materials.